Clemson owns a 7-0 series advantage.
Largest Margin of Victory: 77-16, Clemson 2018
Speakers: Louisville 45, Clemson 968,817,919,173
Louisville is 0-3 in Clemson
All-Time Record: Louisville 538-491-17 (.522), Clemson 786-466-45 (.623)
National Championships: Louisville 0, Clemson 3
Heisman Trophies: Louisville 1, Clemson 0
Articles in Sports Illustrated About Stealing Signals: Louisville 0, Clemson 1
Missing 1st Down Markers: Louisville 0, Clemson 1
Conference Championships: Louisville 9, Clemson 26
Players Positive for Performance Enhancing Drugs (Ostarine): Louisville 0, Clemson 3.
Bowl Games: Louisville 24, Clemson 48
Random Fans Sitting In Opponent Defensive Huddle: Louisville 0, Clemson 1 (at least)
All-Americans: Louisville 3, Clemson 31
NFL Draft Picks: Louisville 128, Clemson 268
NFL 1st Rounders: Louisville 16, Clemson 37
Head Officials in Top 10 match-ups with a child attending Clemson/Louisville: Louisville 0, Clemson 1 (at least)
Weeks in the AP Poll: Louisville 143, Clemson 488
Weeks at AP #1: Louisville 0, Clemson 25
# of times Hosting College GameDay: Louisville 3, Clemson 7
# of times appearing on College GameDay: Louisville 5, Clemson 29
Missing 1st Down Markers: Louisville 0, Clemson 1
Strobes For Opponents: Louisville 0, Clemson 769,654
Eventual Heisman Trophy Winners Choked in the Pile: Louisville 0, Clemson 1 (at least)
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