Notre Dame owns a 1-2 series advantage.
Largest Margin of Victory: 35-17, Notre Dame 2019
Louisville is 0-1 in Louisville vs. The Irish
All-Time Record: Louisville 545-493-17, Notre Dame 943-336-42
National Championships: Louisville 0, Notre Dame 11
Heisman Trophies: Louisville 1, Notre Dame 7
Conference Championships: Louisville 9, Notre Dame 0*
Bowl Games: Louisville 25, Notre Dame 39
All-Americans: Louisville 3, Notre Dame 107
NFL Draft Picks: Louisville 131, Notre Dame 525
NFL 1st Rounders: Louisville 16, Notre Dame 70
Weeks in the AP Poll: Louisville 144, Notre Dame 863
Weeks at AP #1: Louisville 0, Notre Dame 98
# of times Hosting College GameDay: Louisville 3, Notre Dame 10
# of times appearing on College GameDay: Louisville 5, Notre Dame 35
*INDEPENDENT. Only 1 season in ACC (2020)
Series History: Notre Dame Leads 1-2
| Location | Louisville | Notre Dame | Line* | Attendance | |
| 2020 | South Bend, IN | 7 | 12 | +16 | 10.182# |
| 2019 | Louisville, KY | 17 | 35 | +19 | 58,187 |
| 2014 | South Bend, IN | 31 | 28 | +2.5 | 80,795 |
Television Ratings:
| Network | Audience | |
| 2020 | NBC | 3.12M |
| 2019 | ESPN | 5.60M |
| 2014 | NBC | 3.09M |
