University of Louisville running back Isaac Guerendo was selected with the No. 129 pick in the fourth round by the San Fransico 49’ersthe 2024 NFL Draft on Saturday.

Guerendo became Louisville’s 137th draft pick of all time and the 19th running back taken in school history.

The native of Avon, Ind., came to Louisville after spending four seasons in a limited role at Wisconsin. He finished his collegiate career with 1,392 yards and 17 touchdowns. In his lone season with the Cardinals, Guerendo was the team’s second-leading rusher in 2023 with 810 yards and 11 touchdowns, while averaging 6.1 yards a carry.

“Isaac is ready for this next chapter of his career,” head coach Jeff Brohm said “During his one season in our program, he was determined to be great and always took a professional approach on how he did things, both on the football field and in the classroom. He was a great addition to our offense, and he will be a great teammate and leader as he makes the jump to professional football.”

Serving as the team’s second back, Guerendo recorded a pair of 100-yard rushing games, totaling 146 yards and three scores in a win over Virginia. He scored the go-ahead touchdown with 3:24 left to play with a 73-yard touchdown run to secure a 31-24 win over the Cavaliers.

In the Holiday Bowl loss to USC, Guerendo recorded a season high 161 yards and three touchdowns in a 42-28 loss to the Trojans,

The Cardinals have a total of 34 players who have been drafted since 2010 and the eighth in the last four drafts.

Guerendo  is the seventh player in school history to be drafted by San Francisco.

The following two tabs change content below.
@UofLSheriff50. Louisville native, University of Louisville Business School Grad c/o 2004. Co-Founder of

TCZ Comments


1 2 3